Scientific Publications

Pre-clinical Data

Wang Y, Yoshimura R, Manabe H, Schretter C, Clarke R, Cai Y, Fitzgerald M, Lee KS (2014)

‘Trans-sodium crocetinate improves outcomes in rodent models of occlusive and hemorrhagic stroke’ Brain Research 1583:245-254

Manabe H, Wang Y, Yoshimura R, Cai Y, Fitzgerald M, Clarke R, Lee KS (2011)

‘Metabolic reflow as a therapy for ischemic brain injury. H. Feng et al. (eds.), Early Brain Injury or Cerebral Vasospasm, Acta’ Neurochirurgica Supplementum Vol. 110/2, DOI 10.1007/978-3-7091-0356-2_16

John L. Gainer, and Miles F. Lankford3 (2011)

Increasing Oxygen in Hypoxic Tumors

Sheehan J, Popp B, Monteith S, Toulmin A, Tomlinson J, Martin J, Cifarelli C, Lee DH, Park D (2011)

‘Trans sodium crocetinate: functional neuroimaging studies in a hypoxic brain tumor: Laboratory investigation’ J Neurosurg 115:749-753

Sheehan J, Cifarelli C, Dassoulas K, Olson C, Rainey J, Han S (2010)

‘Trans-sodium crocetinate enhancing survival and glioma response on magnetic resonance imaging to radiation and temozolomide: Laboratory investigation’ J Neurosurg 113:234-239

Lapchak PA (2010)

‘Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: a combination therapy study with tissue plasminogen activator’ Brain Research 1309:136-145

Manabe H, Okonkwo DO, Gainer JL, Clarke RH, Lee KS (2010)

’Protection against focal ischemic injury to the brain by trans-sodium crocetinate’ J Neurosurg 113:802-809

Sheehan J, Sherman J, Jagannathan J, Dassoulas K, Cifarelli C Olson C, Rainey J, Han S (2009)

‘Effect of trans sodium crocetinate on brain tumor oxygenation: Laboratory investigation’ J Neurosurg 111:226–229

Sheehan J, Ionescu A, Pouratian N, Hamilton DK, Schlesinger D, Oskouian RJ, Sansur C (2008)

‘Trans sodium crocetinate sensitizes glioblastoma multiforme tumors to radiation’ J Neurosurg 108:972-978.

Clinical Data

Anca Streinu-Cercel, Oana Săndulescu, Victor Daniel Miron, Alina-Alexandra Oană, Maria Magdalena Motoi, Christopher D. Galloway, Adrian Streinu-Cercel

Trans Sodium Crocetinate (TSC) to Improve Oxygenation in COVID-19

Gainer J, Sheehan J, Larner J, Jones D (2016)

‘Trans sodium crocetinate with temozolomide and radiation therapy for glioblastoma multiforme’ J Neurosurg JNS515-2693

Mohler, Gainer, Whitten, Eraso, Thanaporn, Bauer (2011)

‘Evaluation of trans sodium crocetinate on safety and exercise performance in patients with peripheral artery disease and
intermittent claudication’ Vasc Med October; 16(5): 346–353

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